Buffalo is a very small city located in the state of Missouri. With a population of 3,422 people and two associated neighborhoods, Buffalo is the 192nd largest community in Missouri.

A relatively large number of people in Buffalo telecommute to their jobs. Overall, about 7.90% of the workforce works from home. While this may seem like a small number, as a fraction of the total workforce it ranks among the highest in the country. These workers are often telecommuters who work in knowledge-based, white-collar professions. For example, Silicon Valley has large numbers of people who telecommute. Other at-home workers may be self-employed people who operate small businesses out of their homes.

As is often the case in a small city, Buffalo doesn't have a public transportation system that people use for their commute.

In terms of college education, the citizens of Buffalo rank slightly lower than the national average. 14.03% of adults 25 and older in Buffalo have a bachelor's degree or advanced degree, while 21.84% of adults have a 4-year degree or higher in the average American community.

The per capita income in Buffalo in 2022 was $23,205, which is lower middle income relative to Missouri, and low income relative to the rest of the US. This equates to an annual income of $92,820 for a family of four. However, Buffalo contains both very wealthy and poor people as well. Buffalo also has one of the higher rates of people living in poverty in the nation, with 41.23% of its population below the federal poverty line.

The people who call Buffalo home describe themselves as belonging to a variety of racial and ethnic groups. The greatest number of Buffalo residents report their race to be White, followed by Black or African-American. Important ancestries of people in Buffalo include English, German, Irish, Scandinavian, and Russian.

The most common language spoken in Buffalo is English. Other important languages spoken here include Spanish and Italian.