Chillicothe is a medium-sized city located in the state of Ohio. With a population of 21,921 people and 11 associated neighborhoods, Chillicothe is the 78th largest community in Ohio.

In terms of college education, Chillicothe is nearly on par with the US average for all cities of 21.84%: 19.58% of adults 25 and older in Chillicothe have a bachelor's degree or advanced degree.

The per capita income in Chillicothe in 2022 was $34,323, which is upper middle income relative to Ohio, and middle income relative to the rest of the US. This equates to an annual income of $137,292 for a family of four. However, Chillicothe contains both very wealthy and poor people as well.

Chillicothe is a somewhat ethnically-diverse city. The people who call Chillicothe home describe themselves as belonging to a variety of racial and ethnic groups. The greatest number of Chillicothe residents report their race to be White, followed by Black or African-American. Important ancestries of people in Chillicothe include German, Irish, English, Scottish, and Scots-Irish.

The most common language spoken in Chillicothe is English. Other important languages spoken here include German/Yiddish and Spanish.